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Use of High-throughput Enzyme-based Assay with Xenobiotic Metabolic Capability to Evaluate the Inhibition of Acetylcholinesterase Activity by Organophosphorus Pesticides
The inhibition of acetylcholinesterase (AChE) has pharmaceutical applications as well as potential neurotoxic effects. The in vivo metabolites of some chemicals including organophosphorus pesticides can become more potent AChE inhibitors compared to their parental compounds. To account for the effec...
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| Veröffentlicht in: | Toxicol In Vitro |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6713233/ https://ncbi.nlm.nih.gov/pubmed/30625376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2019.01.002 |
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