Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease

Herein, we report the effect of nine FDA approved protease inhibitor drugs against a new HIV-1 subtype C mutant protease, E35D↑G↑S. The mutant has five mutations, E35D, two insertions, position 36 (G and S), and D60E. Kinetics, inhibition constants, vitality, Gibbs free binding energies are reported...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Maseko, Sibusiso, Padayachee, Eden, Maphumulo, Siyabonga, Govender, Thavendran, Sayed, Yasien, Maguire, Glenn, Lin, Johnson, Naicker, Tricia, Baijnath, Sooraj, Gerhardus, Kruger Hendrik
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713120/
https://ncbi.nlm.nih.gov/pubmed/31409143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1636234
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