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Multiple functional variants in the IL1RL1 region are pretransplant markers for risk of GVHD and infection deaths

Graft-versus-host disease (GVHD) and infections are the 2 main causes of death without relapse after allogeneic hematopoietic cell transplantation (HCT). Elevated soluble serum simulation-2 (sST2), the product of IL1RL1 in plasma/serum post-HCT, is a validated GVHD biomarker. Hundreds of SNPs at 2q1...

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Publicat a:Blood Adv
Autors principals: Karaesmen, Ezgi, Hahn, Theresa, Dile, Alexander James, Rizvi, Abbas A., Wang, Junke, Wang, Tao, Haagenson, Michael D., Preus, Leah, Zhu, Qianqian, Liu, Qian, Yan, Li, Liu, Song, Haiman, Christopher A., Stram, Daniel, Pooler, Loreall, Sheng, Xin, Van Den Berg, David, Brock, Guy, Webb, Amy, McCarthy, Philip L., Pasquini, Marcelo C., Spellman, Stephen R., Lee, Stephanie J., Paczesny, Sophie, Sucheston-Campbell, Lara E.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712530/
https://ncbi.nlm.nih.gov/pubmed/31455667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000075
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