Early Histone Deacetylase Inhibition Mitigates Ischemia/Reperfusion Brain Injury by Reducing Microglia Activation and Modulating Their Phenotype

Histone deacetylase inhibitors (HDACi) are a promising therapeutic intervention for stroke. The involvement of the anti-inflammatory effects of HDACi in their neuroprotection has been reported, but the underlying mechanisms are still uncertain. Given the post-stroke inflammation is a time-dependent...

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Bibliographische Detailangaben
Veröffentlicht in:Front Neurol
Hauptverfasser: Li, Shuyuan, Lu, Xiaoshuang, Shao, Qian, Chen, Zixin, Huang, Qiong, Jiao, Zinan, Huang, Xiaodi, Yue, Maosong, Peng, Jingwen, Zhou, Xin, Chao, Dachong, Zhao, Heng, Ji, Juling, Ji, Yuhua, Ji, Qiuhong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Neurology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6710990/
https://ncbi.nlm.nih.gov/pubmed/31481925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2019.00893
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