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Effects of CYP3A inhibitors on the pharmacokinetics of quizartinib, a potent and selective FLT3 inhibitor, and its active metabolite

AIMS: Quizartinib is an oral, highly potent and selective next‐generation FMS‐like tyrosine kinase 3 (FLT3) inhibitor under investigation in patients with FLT3‐internal tandem duplication‐mutated acute myeloid leukaemia. This drug–drug interaction study assessed the pharmacokinetics (PK) of quizarti...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Li, Jianke, Kankam, Martin, Trone, Denise, Gammon, Guy
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6710528/
https://ncbi.nlm.nih.gov/pubmed/31173645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14022
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