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Differential Coupling of the PAC1 SV1 Splice Variant on Human Colonic Tumors to the Activation of Intracellular cAMP but Not Intracellular Ca(2+) Does Not Activate Tumor Proliferation

PAC1 is a recently cloned and characterized heptahelical, G protein-coupled receptor with high affinity to PACAP-27 and PACAP-38 and is differentially coupled to activate intracellular Ca(2+) and cAMP. PAC1 is expressed as four major splice variants, each possessing differential coupling to inositol...

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Detalhes bibliográficos
Publicado no:J Mol Neurosci
Main Authors: Germano, Patrizia M., Le, Sang V., Oh, David S., Fan, Robert, Lieu, Sandy, Siu, Alan, Pisegna, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707513/
https://ncbi.nlm.nih.gov/pubmed/14742913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1385/JMN:22:1-2:83
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