Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens

Therapeutic options to treat primary glioblastoma (GBM) tumors are scarce. GBM tumors with epidermal growth factor receptor (EGFR) mutations, in particular a constitutively active EGFRvIII mutant, have extremely poor clinical outcomes. GBM tumors with concurrent EGFR amplification and active phospha...

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Detalhes bibliográficos
Publicado no:Biomaterials
Main Authors: Pedron, Sara, Wolter, Gabrielle L., Chen, Jee-Wei E., Laken, Sarah E., Sarkaria, Jann N., Harley, Brendan A. C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707069/
https://ncbi.nlm.nih.gov/pubmed/31352310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2019.119371
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