A novel role of glutathione S-transferase A3 in inhibiting hepatic stellate cell activation and rat hepatic fibrosis

BACKGROUND AND AIMS: Glutathione S-transferase A3 (GSTA3) is known as an antioxidative protease, however, the crucial role of GSTA3 in liver fibrosis remains unclear. As a recently we developed water-soluble pyridone agent with antifibrotic features, fluorofenidone (AKF-PD) can attenuate liver fibro...

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Veröffentlicht in:J Transl Med
Hauptverfasser: Chen, Haihua, Gan, Qixin, Yang, Congying, Peng, Xiongqun, Qin, Jiao, Qiu, Sisi, Jiang, Yanzhi, Tu, Sha, He, Ying, Li, Shenglan, Yang, Huixiang, Tao, Lijian, Peng, Yu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6706941/
https://ncbi.nlm.nih.gov/pubmed/31443720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-2027-8
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