Preparation of a Major Metabolite of Iguratimod and Simultaneous Assay of Iguratimod and Its Metabolite by HPLC in Rat Plasma

Iguratimod is a new synthetic disease-modifying antirheumatic drug intended to treat patients with rheumatoid arthritis. A new method using recombinant human CYP450s yeast cells containing c-DNA expressed P450s was applied to identify the metabolic pathways of iguratimod and to prepare its metabolit...

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發表在:Iran J Pharm Res
Main Authors: Han, Jun-ping, Zhu, Zhen-han, Wu, Yue-zhang, Qian, Wen, Li, Zhi-yu, Nishikawa, Miyu, Sakaki, Toshiyuki, Yang, Chang-qing
格式: Artigo
語言:Inglês
出版: Shaheed Beheshti University of Medical Sciences 2019
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6706704/
https://ncbi.nlm.nih.gov/pubmed/31531047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22037/ijpr.2019.1100641
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