Necrostatin-1 Attenuates Renal Ischemia and Reperfusion Injury via Meditation of HIF-1α/mir-26a/TRPC6/PARP1 Signaling

Necroptosis, oxidative stress, and inflammation are major contributors to the pathogenesis of ischemic acute kidney injury. Necrostatin-1 (Nec-1), an inhibitor of the kinase domain of receptor-interacting protein kinase-1 (RIP1), has been reported to regulate renal ischemia and reperfusion (I/R) inj...

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Bibliografski detalji
Izdano u:Mol Ther Nucleic Acids
Glavni autori: Shen, Bingbing, Mei, Mei, Pu, Youmin, Zhang, Huhai, Liu, Hong, Tang, Maozhi, Pan, Qianguang, He, Yue, Wu, Xiongfei, Zhao, Hongwen
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6706591/
https://ncbi.nlm.nih.gov/pubmed/31422287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.06.025
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