Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease

Pancreatic ductal adenocarcinoma (PDA) has a highly immunosuppressive microenvironment, which is contributed by the complex interaction between cancer cells and a heterogeneous population of stromal cells. Therefore, facile and trackable models are needed for integrative and dynamic interrogation of...

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Udgivet i:Sci Rep
Main Authors: Filippini, Dea, Agosto, Sabrina D’, Delfino, Pietro, Simbolo, Michele, Piro, Geny, Rusev, Borislav, Veghini, Lisa, Cantù, Cinzia, Lupo, Francesca, Ugel, Stefano, De Sanctis, Francesco, Bronte, Vincenzo, Milella, Michele, Tortora, Giampaolo, Scarpa, Aldo, Carbone, Carmine, Corbo, Vincenzo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6706454/
https://ncbi.nlm.nih.gov/pubmed/31439856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48663-7
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