Differential Synaptic Remodeling by Dopamine in Direct and Indirect Striatal Projection Neurons in Pitx3(−/−) Mice, a Genetic Model of Parkinson's Disease

In toxin-based models of Parkinson's disease (PD), striatal projection neurons (SPNs) exhibit dendritic atrophy and spine loss concurrent with an increase in excitability. Chronic l-DOPA treatment that induces dyskinesia selectively restores spine density and excitability in indirect pathway SP...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Suarez, Luz M., Alberquilla, Samuel, García-Montes, Jose R., Moratalla, Rosario
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2018
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705913/
https://ncbi.nlm.nih.gov/pubmed/29483281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3184-17.2018
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