The Soluble Form of LOTUS inhibits Nogo Receptor-Mediated Signaling by Interfering with the Interaction Between Nogo Receptor Type 1 and p75 Neurotrophin Receptor

Nogo receptor type 1 (NgR1) is known to inhibit neuronal regeneration in the CNS. Previously, we have shown that lateral olfactory tract usher substance (LOTUS) interacts with NgR1 and inhibits its function by blocking its ligand binding. Therefore, LOTUS is expected to have therapeutic potential fo...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Kawakami, Yutaka, Kurihara, Yuji, Saito, Yu, Fujita, Yuki, Yamashita, Toshihide, Takei, Kohtaro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2018
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705898/
https://ncbi.nlm.nih.gov/pubmed/29440387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0953-17.2018
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