The Dual Function of the Polybasic Juxtamembrane Region of Syntaxin 1A in Clamping Spontaneous Release and Stimulating Ca(2+)-Triggered Release in Neuroendocrine Cells

The exact function of the polybasic juxtamembrane region (5RK) of the plasma membrane neuronal SNARE, syntaxin 1A (Syx), in vesicle exocytosis, although widely studied, is currently not clear. Here, we addressed the role of 5RK in Ca(2+)-triggered release, using our Syx-based intramolecular fluoresc...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Singer-Lahat, Dafna, Barak-Broner, Noa, Sheinin, Anton, Greitzer-Antes, Dafna, Michaelevski, Izhak, Lotan, Ilana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2018
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705805/
https://ncbi.nlm.nih.gov/pubmed/29133430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1541-17.2017
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