Extracellular Zn(2+) Is Essential for Amyloid β(1–42)-Induced Cognitive Decline in the Normal Brain and Its Rescue

Brain Aβ(1–42) accumulation is considered an upstream event in pathogenesis of Alzheimer's disease. However, accumulating evidence indicates that other neurochemical changes potentiate the toxicity of this constitutively generated peptide. Here we report that the interaction of Aβ(1–42) with ex...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Takeda, Atsushi, Tamano, Haruna, Tempaku, Munekazu, Sasaki, Miku, Uematsu, Chihiro, Sato, Shoko, Kanazawa, Hiroaki, Datki, Zsolt L., Adlard, Paul A., Bush, Ashley I.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705735/
https://ncbi.nlm.nih.gov/pubmed/28652412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0954-17.2017
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