Lesion activity and chronic demyelination are the major determinants of brain atrophy in MS

OBJECTIVE: To evaluate the combined effect of lesion activity and pathologic processes occurring in both chronically demyelinated lesions and normal-appearing white matter (NAWM) on brain atrophy in MS. METHODS: Pre- and post-gadolinium T1, fluid attenuation inversion recovery, and diffusion tensor...

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Veröffentlicht in:Neurol Neuroimmunol Neuroinflamm
Hauptverfasser: Wang, Chenyu, Barnett, Michael H., Yiannikas, Con, Barton, Joshua, Parratt, John, You, Yuyi, Graham, Stuart L., Klistorner, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: Lippincott Williams & Wilkins 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705629/
https://ncbi.nlm.nih.gov/pubmed/31454773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000593
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