Unexpected Heterodivalent Recruitment of NOS1AP to nNOS Reveals Multiple Sites for Pharmacological Intervention in Neuronal Disease Models

The protein NOS1AP/CAPON mediates signaling from a protein complex of NMDA receptor, PSD95 and nNOS. The only stroke trial for neuroprotectants that showed benefit to patients targeted this ternary complex. NOS1AP/nNOS interaction regulates small GTPases, iron transport, p38MAPK-linked excitotoxicit...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Li, Li-Li, Melero-Fernandez de Mera, Raquel M., Chen, Jia, Ba, Wei, Kasri, Nael Nadif, Zhang, Mingjie, Courtney, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705433/
https://ncbi.nlm.nih.gov/pubmed/25972165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0037-15.2015
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