The Glycan CA19-9 Promotes Pancreatitis and Pancreatic Cancer in Mice

Glycosylation alterations are indicative of tissue inflammation and neoplasia, but whether these alterations contribute to disease pathogenesis is largely unknown. To study the role of glycan changes in pancreatic disease, we inducibly expressed human Fucosyltransferase 3 and β1,3-Galactosyltransfer...

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Publicado no:Science
Main Authors: Engle, Dannielle D., Tiriac, Hervé, Rivera, Keith D., Pommier, Arnaud, Whalen, Sean, Oni, Tobiloba E., Alagesan, Brinda, Lee, Eun Jung, Yao, Melissa A., Lucito, Matthew S., Spielman, Benjamin, Da Silva, Brandon, Schoepfer, Christina, Wright, Kevin, Creighton, Brianna, Afinowicz, Lauren, Yu, Kenneth, Grützmann, Robert, Aust, Daniela, Gimotty, Phyllis A., Pollard, Katherine S., Hruban, Ralph H., Goggins, Michael G., Pilarsky, Christian, Park, Youngkyu, Pappin, Darryl J., Hollingsworth, Michael A., Tuveson, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705393/
https://ncbi.nlm.nih.gov/pubmed/31221853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw3145
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