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Using Small-Angle Scattering Data and Parametric Machine Learning to Optimize Force Field Parameters for Intrinsically Disordered Proteins

Intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) play important roles in many aspects of normal cell physiology, such as signal transduction and transcription, as well as pathological states, including Alzheimer's, Parkinson's, and Huntingt...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Demerdash, Omar, Shrestha, Utsab R., Petridis, Loukas, Smith, Jeremy C., Mitchell, Julie C., Ramanathan, Arvind
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705226/
https://ncbi.nlm.nih.gov/pubmed/31475155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00064
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