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Inhibiting Subthalamic D(5) Receptor Constitutive Activity Alleviates Abnormal Electrical Activity and Reverses Motor Impairment in a Rat Model of Parkinson's Disease
Burst firing has been reported as a pathological activity of subthalamic nucleus (STN) neurons in Parkinson's disease. However, the origin of bursts and their causal link with motor deficits remain unknown. Here we tested the hypothesis that dopamine D(5) receptors (D(5)Rs), characterized by a...
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| Publicado en: | J Neurosci |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Society for Neuroscience
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6705171/ https://ncbi.nlm.nih.gov/pubmed/24027284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0453-13.2013 |
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