Inhibiting Subthalamic D(5) Receptor Constitutive Activity Alleviates Abnormal Electrical Activity and Reverses Motor Impairment in a Rat Model of Parkinson's Disease

Burst firing has been reported as a pathological activity of subthalamic nucleus (STN) neurons in Parkinson's disease. However, the origin of bursts and their causal link with motor deficits remain unknown. Here we tested the hypothesis that dopamine D(5) receptors (D(5)Rs), characterized by a...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Chetrit, Jonathan, Taupignon, Anne, Froux, Lionel, Morin, Stephanie, Bouali-Benazzouz, Rabia, Naudet, Frédéric, Kadiri, Nabila, Gross, Christian E., Bioulac, Bernard, Benazzouz, Abdelhamid
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705171/
https://ncbi.nlm.nih.gov/pubmed/24027284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0453-13.2013
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