A Novel Transgenic Rat Model for Spinocerebellar Ataxia Type 17 Recapitulates Neuropathological Changes and Supplies In Vivo Imaging Biomarkers

Spinocerebellar ataxia 17 (SCA17) is an autosomal-dominant, late-onset neurodegenerative disorder caused by an expanded polyglutamine (polyQ) repeat in the TATA-box-binding protein (TBP). To further investigate this devastating disease, we sought to create a first transgenic rat model for SCA17 that...

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Publicado en:J Neurosci
Main Authors: Kelp, Alexandra, Koeppen, Arnulf H., Petrasch-Parwez, Elisabeth, Calaminus, Carsten, Bauer, Claudia, Portal, Esteban, Yu-Taeger, Libo, Pichler, Bernd, Bauer, Peter, Riess, Olaf, Nguyen, Huu Phuc
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705027/
https://ncbi.nlm.nih.gov/pubmed/23699518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5622-12.2013
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