Lipoxin A(4) ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial–mesenchymal transition

BACKGROUND: Acute respiratory distress syndrome (ARDS) is characterized by alveolar epithelial disruption. Lipoxins (LXs), as so-called “braking signals” of inflammation, are the first mediators identified to have dual anti-inflammatory and inflammatory pro-resolving properties. METHODS: In vivo, li...

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Veröffentlicht in:Respir Res
Hauptverfasser: Yang, Jing-xiang, Li, Ming, Chen, Xin-ou, Lian, Qing-quan, Wang, Qian, Gao, Fang, Jin, Sheng-wei, Zheng, Sheng-xing
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704532/
https://ncbi.nlm.nih.gov/pubmed/31438948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-019-1158-z
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