Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

Many risk genes for the development of Alzheimer’s disease (AD) are exclusively or highly expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival. We designed and synthesized a highly selective brain-penetrant CSF1R inhibitor (...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Spangenberg, Elizabeth, Severson, Paul L., Hohsfield, Lindsay A., Crapser, Joshua, Zhang, Jiazhong, Burton, Elizabeth A., Zhang, Ying, Spevak, Wayne, Lin, Jack, Phan, Nicole Y., Habets, Gaston, Rymar, Andrey, Tsang, Garson, Walters, Jason, Nespi, Marika, Singh, Parmveer, Broome, Stephanie, Ibrahim, Prabha, Zhang, Chao, Bollag, Gideon, West, Brian L., Green, Kim N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704256/
https://ncbi.nlm.nih.gov/pubmed/31434879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11674-z
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