Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms

Aneurysms and dissections affecting thoracic aorta are associated with smooth muscle cell (SMC) dysfunction. NO/cGMP signaling pathway in smooth muscle cells has been shown to be affected in sporadic thoracic aortic aneurysms. We analyzed the mRNA levels of PDE5, a cGMP-hydrolyzing enzyme highly exp...

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Published in:Sci Rep
Main Authors: Cesarini, Valeriana, Pisano, Calogera, Rossi, Gabriele, Balistreri, Carmela Rita, Botti, Flavia, Antonelli, Giorgio, Ruvolo, Giovanni, Jannini, Emmanuele A., Dolci, Susanna
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704119/
https://ncbi.nlm.nih.gov/pubmed/31434939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48432-6
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