Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

Age-associated changes in CD4 T-cell functionality have been linked to chronic inflammation and decreased immunity. However, a detailed characterization of CD4 T cell phenotypes that could explain these dysregulated functional properties is lacking. We used single-cell RNA sequencing and multidimens...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Elyahu, Yehezqel, Hekselman, Idan, Eizenberg-Magar, Inbal, Berner, Omer, Strominger, Itai, Schiller, Maya, Mittal, Kritika, Nemirovsky, Anna, Eremenko, Ekaterina, Vital, Assaf, Simonovsky, Eyal, Chalifa-Caspi, Vered, Friedman, Nir, Yeger-Lotem, Esti, Monsonego, Alon
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703865/
https://ncbi.nlm.nih.gov/pubmed/31457092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw8330
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