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Inducible Gene Switches with Memory in Human T Cells for Cellular Immunotherapy

[Image: see text] Cell-based therapies that employ engineered T cells—including those modified to express chimeric antigen receptors (CARs)—to target cancer cells have demonstrated promising responses in clinical trials. However, engineered T cell responses must be regulated to prevent severe side e...

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Détails bibliographiques
Publié dans:ACS Synth Biol
Auteurs principaux: Chakravarti, Deboki, Caraballo, Leidy D., Weinberg, Benjamin H., Wong, Wilson W.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2019
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703182/
https://ncbi.nlm.nih.gov/pubmed/31268301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.8b00512
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