Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization

Microbial exposures can define an individual’s basal immune state. Cohousing specific pathogen-free (SPF) mice with pet store mice, which harbor numerous infectious microbes, results in global changes to the immune system, including increased circulating phagocytes and elevated inflammatory cytokine...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Huggins, Matthew A., Sjaastad, Frances V., Pierson, Mark, Kucaba, Tamara A., Swanson, Whitney, Staley, Christopher, Weingarden, Alexa R., Jensen, Isaac J., Danahy, Derek B., Badovinac, Vladimir P., Jameson, Stephen C., Vezys, Vaiva, Masopust, David, Khoruts, Alexander, Griffith, Thomas S., Hamilton, Sara E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703181/
https://ncbi.nlm.nih.gov/pubmed/31412243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.028
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