A VDAC1-Derived N-Terminal Peptide Inhibits Mutant SOD1-VDAC1 Interactions and Toxicity in the SOD1 Model of ALS

Mutations in superoxide dismutase (SOD1) are the second most common cause of familial amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease caused by the death of motor neurons in the brain and spinal cord. SOD1 neurotoxicity has been attributed to aberrant accumulation of misfolded...

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Pubblicato in:Front Cell Neurosci
Autori principali: Shteinfer-Kuzmine, Anna, Argueti, Shirel, Gupta, Rajeev, Shvil, Neta, Abu-Hamad, Salah, Gropper, Yael, Hoeber, Jan, Magrì, Andrea, Messina, Angela, Kozlova, Elena N., Shoshan-Barmatz, Varda, Israelson, Adrian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702328/
https://ncbi.nlm.nih.gov/pubmed/31474832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00346
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