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Hypoxia Enhances Endothelial Intercellular Adhesion Molecule 1 Protein Level Through Upregulation of Arginase Type II and Mitochondrial Oxidative Stress

Hypoxia plays a crucial role in the pathogenesis of cardiovascular diseases. Mitochondrial enzyme arginase type II (Arg-II) is reported to lead to endothelial dysfunction and enhance the expression of endothelial inflammatory adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and...

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Pubblicato in:Front Physiol
Autori principali: Liang, Xiujie, Arullampalam, Prakash, Yang, Zhihong, Ming, Xiu-Fen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702258/
https://ncbi.nlm.nih.gov/pubmed/31474872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01003
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