A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling

CEP104 is an evolutionarily conserved centrosomal and ciliary tip protein. CEP104 loss-of-function mutations are reported in patients with Joubert syndrome, but their function in the etiology of ciliopathies is poorly understood. Here, we show that cep104 silencing in zebrafish causes cilia-related...

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Publicado en:Cell Rep
Autores principales: Frikstad, Kari-Anne M., Molinari, Elisa, Thoresen, Marianne, Ramsbottom, Simon A., Hughes, Frances, Letteboer, Stef J.F., Gilani, Sania, Schink, Kay O., Stokke, Trond, Geimer, Stefan, Pedersen, Lotte B., Giles, Rachel H., Akhmanova, Anna, Roepman, Ronald, Sayer, John A., Patzke, Sebastian
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702141/
https://ncbi.nlm.nih.gov/pubmed/31412255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.025
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