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A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary Ca(V)β subunits
Inhibiting high-voltage-activated calcium channels (HVACCs; Ca(V)1/Ca(V)2) is therapeutic for myriad cardiovascular and neurological diseases. For particular applications, genetically-encoded HVACC blockers may enable channel inhibition with greater tissue-specificity and versatility than is achieva...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6701945/ https://ncbi.nlm.nih.gov/pubmed/31403402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49253 |
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