Single-Cell RNA Transcriptome Helps Define the Limbal/Corneal Epithelial Stem/Early Transit Amplifying Cells and How Autophagy Affects This Population

PURPOSE: Single-cell RNA-sequencing (scRNA-seq) was used to interrogate the relatively rare stem (SC) and early transit amplifying (TA) cell populations in limbal/corneal epithelia from wild-type and autophagy-compromised mice. METHODS: We conducted scRNA-seq on ocular anterior segmental tissue from...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Kaplan, Nihal, Wang, Junyi, Wray, Brian, Patel, Priyam, Yang, Wending, Peng, Han, Lavker, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2019
Assuntos:
Cornea
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701873/
https://ncbi.nlm.nih.gov/pubmed/31419300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.19-27656
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