HIV population-level adaptation can rapidly diminish the impact of a partially effective vaccine

BACKGROUND: Development of an HIV vaccine might be essential to ending the HIV/AIDS pandemic. However, vaccines can result in the emergence and spread of vaccine-resistant strains. Indeed, analyses of breakthrough infections in the HIV phase 3 vaccine trial RV144 identified HIV genotypes with differ...

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Vydáno v:Vaccine
Hlavní autoři: Herbeck, Joshua T., Peebles, Kathryn, Edlefsen, Paul T., Rolland, Morgane, Murphy, James T., Gottlieb, Geoffrey S., Abernethy, Neil, Mullins, James I., Mittler, John E., Goodreau, Steven M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701864/
https://ncbi.nlm.nih.gov/pubmed/29241646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2017.12.004
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