Small-Molecule Activators of Glucose-6-phosphate Dehydrogenase (G6PD) Bridging the Dimer Interface

We recently identified AG1, a small-molecule activator that functions by promoting oligomerization of glucose-6-phosphate dehydrogenase (G6PD) to the catalytically competent forms. Biochemical experiments indicate that the activation of G6PD by the original hit molecule (AG1) is noncovalent and that...

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Udgivet i:ChemMedChem
Main Authors: Raub, Andrew G., Hwang, Sunhee, Horikoshi, Naoki, Cunningham, Anna D., Rahighi, Simin, Wakatsuki, Soichi, Mochly-Rosen, Daria
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701841/
https://ncbi.nlm.nih.gov/pubmed/31183991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900341
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