Targeted quantitative proteomic analysis of drug metabolizing enzymes and transporters by nano LC-MS/MS in the sandwich cultured human hepatocyte model

INTRODUCTION: Sandwich-cultured human hepatocytes (SCHHs) are the most common in vitro hepatocyte model used for studying hepatic drug disposition and hepatotoxicity. Targeted quantification of key DME and transporter protein expression is useful for in vitro-in vivo extrapolation of drug and xenobi...

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Publicado en:J Pharmacol Toxicol Methods
Autores principales: Khatri, Raju, Fallon, John K., Rementer, Rebecca J. B., Kulick, Natasha T., Lee, Craig R., Smith, Philip C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701468/
https://ncbi.nlm.nih.gov/pubmed/31158457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vascn.2019.106590
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