Lysophosphatidic acid receptor 1 (LPA(1)) plays critical roles in microglial activation and brain damage after transient focal cerebral ischemia

BACKGROUND: Lysophosphatidic acid receptor 1 (LPA(1)) is in the spotlight because its synthetic antagonist has been under clinical trials for lung fibrosis and psoriasis. Targeting LPA(1) might also be a therapeutic strategy for cerebral ischemia because LPA(1) triggers microglial activation, a core...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Gaire, Bhakta Prasad, Sapkota, Arjun, Song, Mi-Ryoung, Choi, Ji Woong
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701099/
https://ncbi.nlm.nih.gov/pubmed/31429777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1555-8
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