Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells

Pyruvate is a key metabolite in glycolysis and the tricarboxylic acid (TCA) cycle. Exogenous pyruvate modulates metabolism, provides cellular protection, and is essential for the maintenance of human preimplantation embryos and human embryonic stem cells (hESCs). However, little is known about how p...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Principais autores: Song, Chengcheng, Xu, Faxiang, Ren, Zhili, Zhang, Yumeng, Meng, Ya, Yang, Yiqi, Lingadahalli, Shreyas, Cheung, Edwin, Li, Gang, Liu, Weiwei, Wan, Jianbo, Zhao, Yang, Chen, Guokai
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700476/
https://ncbi.nlm.nih.gov/pubmed/31353224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.06.003
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