Linking Molecular Pathways and Large-Scale Computational Modeling to Assess Candidate Disease Mechanisms and Pharmacodynamics in Alzheimer's Disease

Introduction: While the prevalence of neurodegenerative diseases associated with dementia such as Alzheimer's disease (AD) increases, our knowledge on the underlying mechanisms, outcome predictors, or therapeutic targets is limited. In this work, we demonstrate how computational multi-scale bra...

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Vydáno v:Front Comput Neurosci
Hlavní autoři: Stefanovski, Leon, Triebkorn, Paul, Spiegler, Andreas, Diaz-Cortes, Margarita-Arimatea, Solodkin, Ana, Jirsa, Viktor, McIntosh, Anthony Randal, Ritter, Petra
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700386/
https://ncbi.nlm.nih.gov/pubmed/31456676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncom.2019.00054
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