Mechanism of Action and Clinical Efficacy of CDK4/6 Inhibitors in BRCA-Mutated, Estrogen Receptor-Positive Breast Cancers: Case Report and Literature Review

Sensitivity to endocrine therapy of patients with estrogen receptor (ER)-positive metastatic breast cancer and germline BRCA1/2 mutations is not yet fully elucidated. Furthermore, the registration trials of CDK 4/6 inhibitors in combination with endocrine therapy lacked of a pre-specified subgroup a...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Militello, Anna Maria, Zielli, Teresa, Boggiani, Daniela, Michiara, Maria, Naldi, Nadia, Bortesi, Beatrice, Zanelli, Paola, Uliana, Vera, Giuliotti, Sara, Musolino, Antonino
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700293/
https://ncbi.nlm.nih.gov/pubmed/31456944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00759
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