Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria

Excessive alcohol consumption induces intestinal dysbiosis of the gut microbiome and reduces gut epithelial integrity. This often leads to portal circulation–mediated translocation of gut-derived microbial products, such as lipopolysaccharide (LPS), to the liver, where these products engage Toll-lik...

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Foilsithe in:J Biol Chem
Main Authors: Liang, Shuang, Zhong, Zhenyu, Kim, So Yeon, Uchiyama, Ryosuke, Roh, Yoon Seok, Matsushita, Hiroshi, Gottlieb, Roberta A., Seki, Ekihiro
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2019
Ábhair:
Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699832/
https://ncbi.nlm.nih.gov/pubmed/31235522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007409
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