A High Throughput HPLC-MS/MS Method for Antihypertensive Drugs Determination in Plasma and Its Application on Pharmacokinetic Interaction Study with Shuxuetong Injection in Rats

A high-throughput HPLC-MS/MS method was developed and validated for the determination of four antihypertensive drugs including metoprolol tartrate, hydrochlorothiazide, nifedipine, and valsartan in rat plasma. The Sprague-Dawley rats were randomly divided into three groups: A Group: gastric-administ...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Wei, Juan, Ma, Wenjuan, Yao, Guangzhe, Jia, Qi, Cheng, Xuejing, Ouyang, Huizi, Chang, Yanxu, Chen, Xiaopeng, He, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699285/
https://ncbi.nlm.nih.gov/pubmed/31467909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/7537618
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