Urolithin A‐activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo

AIM: Mitochondrial autophagy (mitophagy) clears damaged mitochondria and attenuates ischemic neuronal injury. Urolithin A (Uro‐A) activates mitophagy in mammal cells and Caenorhabditis elegans. We explored neuroprotection of Uro‐A against ischemic neuronal injury. METHODS: Mice were subjected to mid...

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Vydáno v:CNS Neurosci Ther
Hlavní autoři: Ahsan, Anil, Zheng, Yan‐Rong, Wu, Xiao‐Li, Tang, Wei‐Dong, Liu, Meng‐Ru, Ma, Shi‐Jia, Jiang, Lei, Hu, Wei‐Wei, Zhang, Xiang‐Nan, Chen, Zhong
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698978/
https://ncbi.nlm.nih.gov/pubmed/30972969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.13136
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