Tumor-Directed Blockade of CD47 with Bispecific Antibodies Induces Adaptive Antitumor Immunity

CD47 serves as an anti-phagocytic receptor that is upregulated by cancer to promote immune escape. As such, CD47 is the focus of intense immuno-oncology drug development efforts. However, as CD47 is expressed ubiquitously, clinical development of conventional drugs, e.g., monoclonal antibodies, is c...

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Podrobná bibliografie
Vydáno v:Antibodies (Basel)
Hlavní autoři: Dheilly, Elie, Majocchi, Stefano, Moine, Valéry, Didelot, Gérard, Broyer, Lucile, Calloud, Sébastien, Malinge, Pauline, Chatel, Laurence, Ferlin, Walter G., Kosco-Vilbois, Marie H., Fischer, Nicolas, Masternak, Krzysztof
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698848/
https://ncbi.nlm.nih.gov/pubmed/31544856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib7010003
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