The Pyrin Inflammasome in Health and Disease

The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar to the “guard” mechanism in plants. Rho GTPases act as molecular switches to regulate a variety of signal transduction pat...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Schnappauf, Oskar, Chae, Jae Jin, Kastner, Daniel L., Aksentijevich, Ivona
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698799/
https://ncbi.nlm.nih.gov/pubmed/31456795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01745
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