Ascorbate inducible N259 glycans on prolyl 4-hydroxylase subunit α1 promote hydroxylation and secretion of type I collagen

Ascorbic acid (vitamin C, VC) increases the secretion of mature collagen by promoting the activity of prolyl 4-hydroxylase subunit α 1 (P4HA1). To explore the mechanism involved, we investigated the role of N-linked glycosylation, which can regulate enzyme activity. P4HA1 has two glycosylation sites...

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Publicat a:Cell Mol Life Sci
Autors principals: Shi, Run, Hu, Weimin, Zhang, Yan, Gao, Shanshan, Smith, Andrew H., Ye, Jun, Cai, Lili, Graham, Linda M., Li, Chaoyang
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2019
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698205/
https://ncbi.nlm.nih.gov/pubmed/30919021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-019-03081-w
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