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Reaction mechanisms of Pol IV, RDR2 and DCL3 drive RNA channeling in the siRNA-directed DNA methylation pathway

In eukaryotes with multiple small RNA pathways the mechanisms that channel RNAs within specific pathways are unclear. Here, we reveal the reactions that account for channeling in the siRNA biogenesis phase of the Arabidopsis RNA-directed DNA methylation pathway. The process begins with template DNA...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cell
Hauptverfasser: Singh, Jasleen, Mishra, Vibhor, Wang, Feng, Huang, Hsiao-Yun, Pikaard, Craig S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698059/
https://ncbi.nlm.nih.gov/pubmed/31398324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.008
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