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Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease

Parkinson’s disease (PD) is a debilitating neurodegenerative disorder caused by the loss of midbrain dopamine (DA) neurons. While the cause of DA cell loss in PD is unknown, male sex is a strong risk factor. Aside from the protective actions of sex hormones in females, emerging evidence suggests tha...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lee, Joohyung, Pinares-Garcia, Paulo, Loke, Hannah, Ham, Seungmin, Vilain, Eric, Harley, Vincent R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697880/
https://ncbi.nlm.nih.gov/pubmed/31371505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1900406116
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