The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation

Identification of RNA-interacting pharmacophores could provide chemical probes and, potentially, small molecules for RNA-based therapeutics. Herein, using a high-throughput differential scanning fluorimetry assay, we identified small molecule natural products with the capacity to bind the discrete s...

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Publicado no:Cell Chem Biol
Main Authors: Matarlo, Joe S., Krumpe, Lauren R.H., Heinz, William F., Oh, Daniel, Shenoy, Shilpa R., Thomas, Cheryl L., Goncharova, Ekaterina I., Lockett, Stephen J., O’Keefe, Barry R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697619/
https://ncbi.nlm.nih.gov/pubmed/31155509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.04.011
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