DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations

Enhancer of zeste homolog 2 (EZH2) tri-methylates histone 3 at position lysine 27 (H3K27me3). Overexpression and gain-of-function mutations in EZH2 are regarded as oncogenic drivers in lymphoma and other malignancies due to the silencing of tumor suppressors and differentiation genes. EZH2 inhibitio...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Akpa, Chidimma Agatha, Kleo, Karsten, Lenze, Dido, Oker, Elisabeth, Dimitrova, Lora, Hummel, Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697340/
https://ncbi.nlm.nih.gov/pubmed/31419226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220681
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