Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes

Type 1 diabetes (T1D) is characterized by pancreatic islet infiltration by autoreactive immune cells and a near-total loss of β-cells(1). Restoration of insulin-producing β-cells coupled with immunomodulation to suppress the autoimmune attack has emerged as a potential approach to counter T1D(2–4)....

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Published in:Nat Metab
Main Authors: Dirice, Ercument, Kahraman, Sevim, De Jesus, Dario F., El Ouaamari, Abdelfattah, Basile, Giorgio, Baker, Rocky L., Yigit, Burcu, Piehowski, Paul D., Kim, Mi-Jeong, Dwyer, Alexander J., Ng, Raymond W. S., Schuster, Cornelia, Vethe, Heidrun, Martinov, Tijana, Ishikawa, Yuki, Teo, Adrian Kee Keong, Smith, Richard D., Hu, Jiang, Haskins, Kathryn, Serwold, Thomas, Qian, Wei-Jun, Fife, Brian T., Kissler, Stephan, Kulkarni, Rohit N.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6696912/
https://ncbi.nlm.nih.gov/pubmed/31423480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0061-8
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